Improving outcome of catheter ablation for VT

Improving outcome of catheter ablation for VT


Functional substrate mapping and ablation for post-infarct VT

We have demonstrated that evoked delayed potential mapping and ablation in patients with post-myocardial infarction VT and, in particular, in patients with non-transmural small infarctions after acute reperfusion, is associated with excellent outcome on follow-up.

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Since 2019, patients with prior myocardial infarction undergoing VT ablation based on EDP elimination at 6 international centers are included in a prospective registry. Our aims are to assess EDP ablation outcome when performed at different centers following a uniform protocol and to identify patients who benefit most from this substrate modification approach.

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Our objective is to assess the accuracy of simultaneous conventional and micro-electrode mapping using the QDOT catheter for EDP identification in patients with prior myocardial infarction compared to multielectrode mapping with the Pentaray catheter.

This project focuses on finding an accurate parameter used to quantify viable myocardium in patients with ICM and use it to predict heart failure events. The proposed parameter is easily available from mapping and is validated in a second consecutive cohort.

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The treatment of recurrent ventricular tachycardia in patients with DCM can be challenging. Although catheter ablation is increasingly being performed, real world data on long-term outcome after ablation is only sparsely available. This large international multicenter registry of 9 tertiary centers on 3 continents was initiated by WECAM electrophysiologists. We aim to provide data on outcome of VT ablation to enable optimal patient selection, ablation and follow-up strategies.

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Key publications

Myocardial calcification is associated with endocardial ablation failure of post-myocardial infarction ventricular tachycardia.
Edition: 1099-5129 | Pages: 1275-1284
The prognostic value of J-wave pattern for recurrence of ventricular tachycardia after catheter ablation in patients with myocardial infarction.
Edition: 0147-8389 | Pages: 657-666
New Adjusted Cutoffs for "Normal" Endocardial Voltages in Patients With Post-Infarct LV Remodeling.
Edition: 2405-500X | Pages: 1115-1126
Multisize Electrodes for Substrate Identification in Ischemic Cardiomyopathy: Validation by Integration of Whole Heart Histology.
Edition: 2405-500X | Pages: 1130-1140
Targeting the Hidden Substrate Unmasked by Right Ventricular Extrastimulation Improves Ventricular Tachycardia Ablation Outcome After Myocardial Infarction.
Edition: 2405-500X | Pages: 316-327
Fast nonclinical ventricular tachycardia inducible after ablation in patients with structural heart disease: Definition and clinical implications.
Edition: 1547-5271 | Pages: 668-676
An easy-to-use, operator-independent, clinical model to predict the left vs. right ventricular outflow tract origin of ventricular arrhythmias.
Edition: 1099-5129 | Pages: 1122-1128
Influence of steroid therapy on the incidence of pericarditis and atrial fibrillation after percutaneous epicardial mapping and ablation for ventricular tachycardia.
Edition: 1941-3149 | Pages: 671-676
Endocardial or epicardial ventricular tachycardia in nonischemic cardiomyopathy? The role of 12-lead ECG criteria in clinical practice.
Edition: 1547-5271 | Pages: 1031-1039
Neurohormonal, structural, and functional recovery pattern after premature ventricular complex ablation is independent of structural heart disease status in patients with depressed left ventricular ejection fraction: a prospective multicenter study.
Edition: 0735-1097 | Pages: 1195-1202
ECG identification of scar-related ventricular tachycardia with a left bundle-branch block configuration.
Edition: 1941-3149 | Pages: 486-493
Early reperfusion therapy affects inducibility, cycle length, and occurrence of ventricular tachycardia late after myocardial infarction.
Edition: 1941-3149 | Pages: 195-201
Reversed polarity of bipolar electrograms for predicting a successful ablation site in focal idiopathic right ventricular outflow tract arrhythmias.
Edition: 1547-5271 | Pages: 665-671
Beneficial effects of catheter ablation on left ventricular and right ventricular function in patients with frequent premature ventricular contractions and preserved ejection fraction.
Edition: 1355-6037 | Pages: 1275-1280
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