Only a minority of post-MI patients with left ventricular ejection fraction (LVEF) ≤35% that currently receive a prophylactic implantable cardioverter defibrillator (ICD) will ever need the device. Others are only exposed to potentially severe complications due to the implantation. According to current guidelines, patients with LVEF >35% are not eligible for ICD implantation. However, in absolute numbers most deaths due to sudden cardiac death (SCD) occur in exactly this group. The PROFID project aims to a) develop a clinical prediction model incorporating a variety of parameters that predict the individual risk for SCD, and b) to compare a personalised decision on ICD implantation based on the individual risk, determined by the prediction model, against current practice in two independent prospective trials.

Clinicaltrials.gov identifier: NCT04540354 (PROFID Reduced), NCT04540289 (PROFID Preserved).

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