Advanced image acquisition and post-processing for in vivo arrhythmia substrate visualization

Advanced image acquisition and post-processing for in vivo arrhythmia substrate visualization

In collaboration with researchers of the technical University Delft and the LKEB our WECAM team has developed a sophisticated program for real-time multimodal image integration. Accurate integration of all imaging-derived data during the mapping and ablation procedure facilitates the procedure and contributes to patient safety and improved outcome. The reversed registration of datasets provides important insights and is key to further develop methods for arrhythmia substrate identification and delineation by imaging.  


Integration of whole heart histology, ex-vivo imaging and arrhythmia substrate mapping

A developed and established workflow for high resolution ex-vivo imaging of pig hearts that underwent an early re-perfusion infarction with accurate integration of in-vivo mapping data and whole heart histology is currently used to validate the performance of novel catheters to delineate scar and arrhythmias substrates.

project ex vivo imaging wecam
project advanced image acquisition wecam
project integration of whole heart histology wecam

ACHD substrate visualization

Key reviews

Advancement in cardiac imaging for treatment of ventricular arrhythmias in structural heart disease.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
Edition: 1099-5129 | Pages: 383-403
Imaging-guided Ventricular Tachycardia Ablation.
Arrhythmia & electrophysiology review
Edition: 2050-3369 | Pages: 128-134

Key publications

Mini-, Micro-, and Conventional Electrodes: An in Vivo Electrophysiology and Ex Vivo Histology Head-to-Head Comparison.
Edition: 2405-500X | Pages: 197-205
Unipolar Endocardial Voltage Mapping in the Right Ventricle: Optimal Cutoff Values Correcting for Computed Tomography-Derived Epicardial Fat Thickness and Their Clinical Value for Substrate Delineation.
Edition: 1941-3149
Preprocedural magnetic resonance imaging for image-guided catheter ablation of scar-related ventricular tachycardia.
Edition: 1569-5794 | Pages: 369-377
Super-resolution reconstruction of late gadolinium-enhanced MRI for improved myocardial scar assessment.
Edition: 1053-1807 | Pages: 160-167
CMR-based identification of critical isthmus sites of ischemic and nonischemic ventricular tachycardia.
Edition: 1936-878X | Pages: 774-784
Improved myocardial scar characterization by super-resolution reconstruction in late gadolinium enhanced MRI.
| Pages: 147-154
Real-time integration of MDCT-derived coronary anatomy and epicardial fat: impact on epicardial electroanatomic mapping and ablation for ventricular arrhythmias.
Edition: 1936-878X | Pages: 42-52
Epicardial substrate mapping for ventricular tachycardia ablation in patients with non-ischaemic cardiomyopathy: a new algorithm to differentiate between scar and viable myocardium developed by simultaneous integration of computed tomography and contrast-enhanced magnetic resonance imaging.
Edition: 0195-668X | Pages: 586-596
CMR-determined scar volume: predictive for ventricular tachycardias?
Edition: 1569-5794 | Pages: 989-993
Toward magnetic resonance-guided electroanatomical voltage mapping for catheter ablation of scar-related ventricular tachycardia: a comparison of registration methods.
Edition: 1045-3873 | Pages: 74-80
Head-to-head comparison of contrast-enhanced magnetic resonance imaging and electroanatomical voltage mapping to assess post-infarct scar characteristics in patients with ventricular tachycardias: real-time image integration and reversed registration.
Edition: 0195-668X | Pages: 104-114
Automated segmentation of myocardial scar in late enhancement MRI using combined intensity and spatial information.
Edition: 0740-3194 | Pages: 586-594
Infarct tissue heterogeneity assessed with contrast-enhanced MRI predicts spontaneous ventricular arrhythmia in patients with ischemic cardiomyopathy and implantable cardioverter-defibrillator.
Edition: 1941-9651 | Pages: 183-190
Real-time integration of intracardiac echocardiography and multislice computed tomography to guide radiofrequency catheter ablation for atrial fibrillation.
Edition: 1547-5271 | Pages: 1403-1410
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